Moderna Analyst Takes On The Coronavirus Vaccine Developer's Pipeline

3 Moderna Analyst Takes On The Coronavirus Vaccine Developer's Pipeline

Coronavirus vaccine developer Moderna Inc MRNA held a virtual R&D event Thursday, showcasing its portfolio and key therapeutic areas.

The Moderna Analysts: Chardan analyst Geulah Livshits has a Buy rating on Moderna with a $95 price target. 

SVB Leerink analyst Mani Foroohar maintained an Underperform rating and $41 price target.

Needham analyst Alan Carr reiterated a Buy rating and $94 price target.

Chardan's 5 Takeaways On Moderna: The news from Moderna's R&D day includes additional visibility on statistical assumptions, monitoring, and data analysis for the Phase 3 COVE study of the SARS-CoV-2 vaccine candidate mRNA-1273, Livshits said in a note.

To increase transparency, Moderna has made the trial protocol available online, the analyst said. 

The first interim analysis of data from the study — at 53 coronavirus cases — is likely to be released in November, she said, citing the company.

The following are Chardan's key takeaways from the event:

The likelihood of the first interim analysis in the Phase 3 trial meeting primary efficacy criteria varies considerably based on vaccine efficacy, with a greater than 50% probability at 75% efficacy, Livshits said.

The results for the CMV vaccine mRNA-1647 in the Phase 2 trial seem better than in Phase 1 data vis-à-vis immunogenicity, tolerability, and a commercial (lyophilized) formulation, the analyst said.

Moderna sees opportunities for combination vaccines in older and younger populations, she said. 

"Systemic mRNA re-dosing appears feasible from a safety standpoint and novel, iterative, trial designs may help select optimal dose levels and schedules." 

Intratumoral delivery induces expression of the encoded proteins and appears to trigger immunological changes, though whether these translate to responses remains to be seen, according to Chardan. 

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William K. 1 month ago Member's comment

OK, now we hear that a vaccine is in the works and should be available in a year or so. and that should be good news for those still around to benefit from it. And the secondary benefit will be a lot less crowding nearly everywhere. Except in cemeteries. Thus Moderna is another good investment.

Dick Kaplan 4 weeks ago Member's comment

Keep in mind that even with a vaccine, Fauci said we'd have to wait nearly a year before it would be "safe" to go the the theater again.

William K. 4 weeks ago Member's comment

A bit of additional information posted elsewhere reminds us that production of any vaccine or medication will take a while and that getting the majority of folks vaccinated will be a long and tedious process. And even if enough for everybody were available tomorrow, the logistics of vaccination will take quite a while. Recall the long lines for the TB and polio vaccinations back in the 1950's. And that was with a community willing and able with no noisy opposition.