Large Cap Biopharma Boosts Portfolio Gains

Large-cap biopharma stocks like Merck and Amgen offer growth and dividends, buffering portfolios against tech volatility.

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  • Large-cap biopharma provides growth plus dividends and drives M&A for pipeline replenishment.

  • Biotech stocks boost healthcare portfolios with innovation and new products.

  • Offers balance to InfoTech portfolios yet can benefit from AI applications.

Away from the volatility and daily headlines of AI and InfoTech, you can add some biotech stocks to buffer your portfolio. Large-cap biopharma stocks offer growth plus dividends and are more immune to geopolitical and economic events.

Here are some takeaways from the data below and the pharmaceutical sector overall:

  1. If you don't want to pick stocks, a good option is to buy the IBB up over 17% YTD and 44% over one year, or just buy the Fidelity Select Biotech Sector Fund (FBIOX) up 17% YTD, 43.7% over one year.

  2. We also own shares in SWISS pharma companies Novartis (NVS) up 10.63% YTD and Roche ADR (RHHBY) up 7.39% YTD.

  3. Two plays for laggard stocks are: AZN for M&A and PFE for value and yield, with key execs buying Pfizer stock

  4. AMGN is the best performer, yet the analyst summary is not bullish?

  5. Our largest positions are AbbVie (ABBV), Lilly (LLY), and Novartis

  6. When in doubt on a trade, RSI or momentum is a good indicator.

  7. The XBI and the IWM are good indicators for overall biotech and SMID biotech strength.

  8. Merck (MRK) is the best performer, 29% YTD and 61% over one year. RSI is a robust 68. 

Analyst

p

PRICE

PRICE

52 wk

Top Biopharmas

TICKER

PICK

TECH

Fwd/PE

Summ

2022

11/23

7/12/25

1/4/26

8/16/26

1 yr %

YTD

div %

RSI

high

Abbvie

ABBV

B

U

15.25

1.59

161.64

138.59

192.45

220

249.46

21.88

9.12

2.77

51

267

PEG 70

Amgen

AMGN

H

U

17

2.43

275

303

292.27

327.64

415.21

43

26.86

2.36

70

422

Rev up 9%

Astra Zeneca

AZN

B/H

D

13.6

1.5

68

63.17

71.13

91.57

156.45

0.37

-15.45

2.04

34.51

212.7

M&A?

Bristol Myers Sq

BMY

B/H

U

9.74

2.45

71.05

50.61

59

63.83

57

33.51

18.34

3.66

56.54

66.97

EPS QoQ

Eli Lilly

LLY

B

U

25.28

1.59

447.71

597.71

793.01

1180

1005

72.83

9.82

0.58

50.06

1199

PEG 83

Gilead Science

GILD

B

F

13.99

1.57

85.39

75.92

109.64

118

138.36

64

29

2.52

62

157

PB 6.84

Merck

MRK

B

U

14.21

1.84

110.95

103

106.45

91.45

135.84

48.1

29

3.05

68.68

125.1

P/B 6

Pfizer

PFE

B

F

9.26

2.55

51.24

29.48

25.18

25.87

26.79

6.69

7.59

6.79

68.9

28.5

P/S 2.2

Regeneron

REGN

B

F/U

13.3

1.57

725

798

567.74

776.3

803

41.97

4.1

0.43

77.3

803

RS 77

Vertex

VRTX

H/B

F/U

23.72

1.56

289

373.65

468.85

505.75

437

29.58

11.56

0

56.49

519

P/B 5.74

Van Eck ETF

PPH

B

U

103.72

110.86

28.68

7.45

1.96

52.58

112.58

LLY,NVS,MRK, NVO

iShares

IBB

B

U

169

198.26

44.4

17.47

0.21

63.18

198

AMGN GILD, VRTX REGN


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