Casinos should have a "huge year" in 2021, and the stocks will be up against very easy comparisons, CNBC's Jim Cramer said Monday on "Mad Money."

What Happened: The U.S. joined a handful of other countries in beginning the distribution of a vaccine against the novel coronavirus this week.

As the number of vaccinated people shifts from dozens to tens of millions over the coming months, the economy could usher in a rebound in travel, especially to casino destinations, Cramer said.

"Americans are ready to gamble again," he said. 

Why It's Important: The case for buying casino stocks is based on a lot more than just "enormous" pent-up demand and upcoming earnings reports that will stack up against a dismal 2020, Cramer said. 

For example, Las Vegas Sands Corp. LVS saw a 76% decline in business over the first nine months of 2020.