E Taking A Long View

EPI01 uses two drugs to inhibit DNMT1, an enzyme that epigenetically silences fetal hemoglobin, which improves outcomes in sickle cell patients by interfering with the polymerization of mutated sickle hemoglobin. With decitabine inhibiting DNMT1, thereby increasing fetal hemoglobin, outlooks should improve. However another human enzyme inactivates decitabine, why it is combined with with tetrahydrouridine, a CDA inhibitor that keeps decitabine levels high enough for the drug to take effect. EpiDestiny is keeping rights to develop the drug in cancer indications.


VALE fell over fear of tariffs on Chinese steel. This daily switch in outlook between bulls and bears is so boring I will stop covering it.

MMC Norilsk Nickel has finally been targeted by US anti-Putin measures. On April 6 Treasury Secretary Steve Mnuchin revealed sanctions against seven Russian tycoons, 12 companies and 17 senior government officials including key allies of the Russian president under a law Congress passed last year to retaliate against Moscow for meddling in the 2016 U.S. presidential election. Among those sanctioned is Oleg Deripaska, 50, who is a top holder of NILSY but doesn't control the company. Its shares fell 0.8%. Deripaska, 50 had links to Trump’s former campaign manager, Paul Manafort. He lives in London where NILSY is listed.

I continue to own the world's largest private sector uranium miner, a rare pure play on U3O8 despite its sales decline of 11% last year and losses. Cameco's SEC filing gives me hope for nuclear. CCJ supplied a “tour d'horizon” on nuclear demand. There has been a uranium glut since the 2011 Fukushima disaster as uranium power plans were shelved and existing operations shut in.

China continued to face excess capacity in the energy sector and first-of-a-kind reactor delays on its AP1000 and EPR reactors. It has not abandoned nuclear. Moreover, with Xi Jinping life-time president, China will continue with its ambitious nuclear growth. Bloomberg says nuclear installed capacity could increase tenfold between 2016 and 2050 to over 300 GW in China.

South Korea’s new government plans to phase-out nuclear power. However, a public panel voted to complete 2 reactors under construction that the government had previously suspended.

France's Macron government reaffirmed its commitment to reduce its reliance on nuclear by 2025, but later was forced to withdraw the target as unrealistic, postponing the reduction to 2030-2035. It is a major nuclear electricity producer.

Construction began on the first nuclear plants in Turkey and Bangladesh. Egypt signed a contract with Russia to build four reactors.

Saudi Arabia is prequalifying reactor vendors as it plans for its first nuclear power plant. It expects to, and plans to, install 17 marking progress on its ambitions to install 17 gigawatts of nuclear capacity by 2040.

Forced and premature shut-downs after Fukushima were emotional, but Japan is now safely bringing reactors online. This means Japanese restarts, successful commissioning of new reactors under construction, and continued development of new construction plans. Japanese utilities have now successfully navigated through the new, rigorous safety inspection process, with the restart of five reactors and another four to restart in 2018.

Having closed its nuclear plants, Germany acknowledged that it can no longer to meet its climate goals despite its substantial rollout of renewable energy with government subsidies.

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Vivian Lewis 2 years ago Author's comment

I always inform my bank if I plan to travel to foreign lands to make sure that my credit cards will work and I can get money from local ATMs. The problems arise DESPITE my warning the bank. I think it is poor internal communications and overuse of cheap Asian labor.

Kurt Benson 2 years ago Member's comment

I've had the same problem. I remember one time there was several thousand dollars of fraud on my account. But then another time I was unable to use my credit card because of a "suspicious charge" for $1.50. A charge I had actually made. Baffling.

Gary Anderson 2 years ago Contributor's comment

Fascinating discussion of HSBC and international banking glitches. It is also a great argument why going cashless can put travelers at risk in the future.

Vivian Lewis 2 years ago Author's comment